The Endocochlear Potential Alters Cochlear Micromechanics
نویسندگان
چکیده
منابع مشابه
The endocochlear potential alters cochlear micromechanics.
Acoustic stimulation gates mechanically sensitive ion channels in cochlear sensory hair cells. Even in the absence of sound, a fraction of these channels remains open, forming a conductance between hair cells and the adjacent fluid space, scala media. Restoring the lost endogenous polarization of scala media in an in vitro preparation of the whole cochlea depolarizes the hair cell soma. Using b...
متن کاملSupporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential.
The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endocochlear potential and requires a highly specialized environment that enables and sustains sensory function. Disturbance of cochlear homeostasis is the cause of many forms of hearing loss including the most frequently occurring syndromic and non-syndromic forms of her...
متن کاملModelling Cochlear Micromechanics
The cochlea is an organ of the hearing system, whose basic function is to map sounds of different frequencies onto corresponding characteristic positions along the basilar membrane (BM). Sound-induced BM vibration is transformed into deflection of stereocilia on the hair cells, which then encodes the sound as neural signals for perception. Most cochlear models used to describe the BM vibration ...
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One of the basic questions which as persisted in the field of heating theory is the still unresolved mechanical action of hair-cell transduction. The fundamental problem that has historically plagued researches is the discrepancy between mechanically measured tuning of basilar membrane motion and neurally measured tuning. Inthis paper we show that he difference between these two measures appear...
متن کاملK+ cycling and the endocochlear potential.
Sensory transduction in the cochlea and the vestibular labyrinth depends on the cycling of K+. In the cochlea, endolymphatic K+ flows into the sensory hair cells via the apical transduction channel and is released from the hair cells into perilymph via basolateral K+ channels including KCNQ4. K+ may be taken up by fibrocytes in the spiral ligament and transported from cell to cell via gap junct...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.05.002